탄산아파타이트르 된 인공골과 소뼈에서 유래한 무기질 골의 초기 골전도에 대한 연구
A study about early osteoconductivity of porous alloplastic carbonapatite and anorganic bovine xenograft in canine maixlliary augmentation model
김도균, 조태형, 송윤미, 김인숙, 황순정, 진임건, 판휘, 이수연, 홍국선,
소속 상세정보
김도균 ( Kim Do-Kyun ) - 서울대학교 치과대학 구강악안면외과학교실
조태형 ( Cho Tae-Hyung ) - 서울대학교 치학연구소
송윤미 ( Song Yun-Mi ) - 서울대학교 치학연구소
김인숙 ( Kim In-Sook ) - 서울대학교 치학연구소
황순정 ( Hwang Soon-Jung ) - 서울대학교 치과대학 구강악안면외과학교실
진임건 ( Jin Im-Geon ) - 서울대학교 치의학대학원 구강악안면외과학교실
판휘 ( Pan Hui ) - 서울대학교 치과대학 구강악안면외과학교실
이수연 ( Lee Su-Yeon ) - 서울대학교 치과대학 구강악안면외과학교실
홍국선 ( Hong Kug-Sun ) - 서울대학교 공과대학 재료공학부
KMID : 0360120070290060485
Abstract
Introduction: Although several types of calcium-phosphate coumpound have been frequently applied to osseous defects at maxillofacial area for many years, there is a controversy about its efficiency on bone conductivity comprared to xenograft bone substitute. Alloplastic carbonapatite has been introduced to improve disadvantages of hydroxyapatite and to mimic natural bone containing carbon elements. However, a preclinical study about its efficiency of osteoconductivity has not been reported. This study was performed to evaluate the early osteoconductive potential of synthetic carbonapatite with multiple pores relative to anorganic bovine xenograft.
Material and Methods : Total 5 beagle dogs were used for maxillary augmentation model. The control (anorganic bovine xenograft) and experimental groups (synthetic carbonapatite) were randomly distributed in the mouth split design. After bone graft, all animals were sacrificed 4 weeks after surgery. Histological specimens with Masson Trichrome staining were made and histomorphometrically analysed with image analyser. The statistical analysis was performed using paired t-test.
Results: In both groups, all animals had no complications. The experimental group showed relatively much new bone formation around and along the bone substitutes, whereas it was clearly reduced in the control group. The ratios of new bone area to total area, to material area and to the residual area excluding materials were higher in the experimental group (0.13+/-0.03, 0.40+/-0.13, 0.20+/-0.06 respectively) than in the control group (0.01+/-0.01, 0.03+/-0.02, 0.03+/-0.03, respectively). And the differences between both groups were statistically significant (p<0.001, <0.01, <0.01, respectively), while the ratio of material area to total area in two groups was not significant.
Conclusion: Carbonapatite showed a high osteoconductivity in the early stage of bone healing compared to bovine derived anorganic bone substitute. This study suggests that this bone materials can be applied as a reliable bone substitute in the clinical treatment.
키워드
Carbonapatite; Multiple pores; Osteoconduction; Anorganic bovine xenograft; Early stage; Bone regeneration
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